Western-style diet impedes colonization and clearance of Citrobacter rodentium
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چکیده
منابع مشابه
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection
Food poisoning is one of the leading causes of morbidity and mortality in the world. Citrobacter rodentium is an enteric pathogen which attaches itself to enterocytes and induces attachment and effacing (A/E) lesions. The ability of the bacterium to cause infection requires subversion of the host actin cytoskeleton. Rac-dependent actin polymerization is activated by a guanine nucleotide exchang...
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Diarrheal diseases are the second highest cause of mortality of children under 5 years worldwide. There is a continuous search for developing a cost-effective treatment for diarrhea as the present ones are facing challenges. Medicinal plants can be explored further as an alternative treatment for diarrhea. Psidium guajava leaves have been used as an antidiarrheal globally. Citrobacter rodentium...
متن کاملDynamic Changes in Mucus Thickness and Ion Secretion during Citrobacter rodentium Infection and Clearance
Citrobacter rodentium is an attaching and effacing pathogen used as a murine model for enteropathogenic Escherichia coli. The mucus layers are a complex matrix of molecules, and mucus swelling, hydration and permeability are affected by many factors, including ion composition. Here, we used the C. rodentium model to investigate mucus dynamics during infection. By measuring the mucus layer thick...
متن کاملCitrobacter rodentium Relies on Commensals for Colonization of the Colonic Mucosa
We investigated the role of commensals at the peak of infection with the colonic mouse pathogen Citrobacter rodentium. Bioluminescent and kanamycin (Kan)-resistant C. rodentium persisted avirulently in the cecal lumen of mice continuously treated with Kan. A single Kan treatment was sufficient to displace C. rodentium from the colonic mucosa, a phenomenon not observed following treatment with v...
متن کاملInflammasome Activation by ATP Enhances Citrobacter rodentium Clearance through ROS Generation.
BACKGROUND Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein complex (inflammasome) that triggers the maturation and secretion of interleukin (IL)-1β and IL-18. We aimed to define the consequences of NLRP3 induction, utilizing exogenous adenosine triphosphate (ATP) as an infla...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2021
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1009497